Use of CAR T Cell Therapy for B-cell ALL

One such treatment option for B-cell ALL is chimeric antigen receptor (CAR) T cell immunotherapy directed against the CD19 protein.

Depending on the stage of disease, HCC can be treated with surgery, chemotherapy, targeted therapies, and radiation.^[4] Current clinical trials are tackling unresectable or advanced stage HCC with mono or combination immunotherapy, monoclonal antibodies or oncolytic virus therapy.^[1-4] These approaches have demonstrated

NOD-scid IL2R?null (NSG) mice engrafted with human peripheral blood mononuclear cells (hPBMCs) have been utilized in xenograft models with success to evaluate efficacy and pharmacodynamics of immune checkpoint inhibitors targeting epitopes on human T-Lymphocytes1.

Lung cancer is the leading cause of cancer-related deaths in the world with non-small cell lung cancer (NSCLC) making up about 85% of all lung cancer cases. With the identification of particular tyrosine kinase mutations, such as EGFR and ALK, targeted therapies shifted the paradigm of drug discovery for NSCLC.

In an effort to more effectively evaluate treatments preclinically, Labcorp offers a human AML model, MV(4;11) (FUW-Luc-mCherry-puro), that has been modified to include both luciferase and mCherry reporter constructs.  Through expression of luciferase, bioluminescent imaging (BLI) can be used to quantitatively measure and track in vivo

Multiple myeloma is a clonal B cell malignancy characterized by the accumulation of terminally differentiated, antibody-producing plasma cells in the bone marrow. Genetic mutations within the myeloma cells and their interaction with various cytokines and growth factors contribute to the invasiveness of the disease and enhanced drug resistance.

Prognosis with pancreatic cancer is extremely poor, with a 5-year relative survival rate of 5% and median survival of 3.5 months for patients with Stage III non-resectable tumors.1 Unfortunately, the incidence of pancreatic cancer has been on the rise while the 5-year survival rate has not changed.

Introduction

At the protein level, humans and mice have similar, and at times nearly identical, amino acid sequences (Table 1).

One of these models is the MDA-MB-231 human breast adenocarcinoma cell line; which was derived from a metastatic site in a 51 year old Caucasian woman. This model has proven to be very valuable to the cancer research community.

While numerous assays are available to measure antigen specificity, many of these have limitations as they necessitate the use of model-specific reagents, genetically engineered animals, or cell subset purification steps. Our Preclinical Oncology offers a simplistic and affordable solution through ELISpot/FluoroSpot analysis.