ALL is more commonly found in young children but also arises in older adults. Children have a >80% cure rate while adults only have a 20-30% cure rate. A similar disease is chronic lymphocytic leukemia (CLL) which is generally diagnosed in older adults.

Even though a number of advances have been made in cancer treatments and surgical approaches, little progress in ovarian cancer therapy has provided a meaningful impact on this patient population.

Researchers use preclinical mouse modeling of lymphoma to explore novel combination strategies of conventional chemotherapy or radiation and immunomodulatory agents.

Contact the preclinical oncology scientific team to learn more. 

Most prostate cancers are adenocarcinomas that develop from the gland cells that produce seminal fluid.

New oncology drugs only have a 3.4% success rate once making it from Phase I clinical trials to FDA approval. This is the lowest success rate among the 21 major disease indications.1 This poor success rate leaves everyone, from the patients to the benchtop scientists, questioning the validity of the models and the resulting data.

Growth of tumor cells within the bone marrow is a common phenomenon in hematologic malignancies.

In this Tech Spotlight we will present an overview of some of the different non-invasive mouse imaging modalities we offer and the advantages of these services in biodistribution studies, monitoring of treatment efficacy and molecular target assessment of disease in tumor models.

2D in vitro assays do not reflect the tumor architecture and environment found in vivo, resulting in differences in the outcomes and pharmacological potencies of test agents being screened when comparing 2D in vitro versus in vivo models.

Animal models can be very powerful tools for analyzing the development and progression of cancer. One example of this is the transgenic polyoma middle T oncoprotein (PyMT) model.