The study found that brain metastases in melanoma had a weaker immune response compared to primary skin, lymph node, and other metastatic sites, suggesting reduced immune cell infiltration and expression of immune checkpoint inhibitor targets.

Metastatic triple-negative breast cancer (TNBC) exhibits increased inflammation and higher expression of checkpoint targets compared to non-TNBC cases, with a paradoxical finding that lower PD-L1 expression is associated with better overall survival.

Authors:

Assays monitoring circulating tumor DNA (ctDNA) have the potential to predict early resistance to immunotherapy and allow for early intervention.

Authors:

Present

Presented b