The industry is facing new and emerging human toxicity concerns driven by worldwide consumer demand and changes to global living standards. From added microplastics and other substances classed as persistent, bioaccumulative and toxic - there is increasing scrutiny placed on the safety profile of your chemical.

Gases, by their very nature, are difficult to handle and analyze. They are, however, generally bound by the same regulatory requirements as solid or liquid substances, so the same endpoint data is required. Physicochemical endpoints such as partition coefficient are requested because they are used to estimate the bioaccumulation potential of a substance.

QSARs are valuable in silico tools that are used in combination with other NATs to answer regulatory questions about the likely toxicity of a new chemical. Many different QSAR systems exist, each with different strengths and weaknesses.

WC11 2021 -- Atherosclerosis (gradual narrowing of the arteries) is an inflammatory process involving a series of progressive cellular events, including monocyte adhesion to the luminal endothelial surface.

As part of a regulatory submission, we were approached by a European company who had been asked by regulators to supply additional operator exposure data. The substance under investigation contained both a pesticide and growth inhibitor, which is applied as a dust to stored potatoes.

An emerging biopharmaceutical company was considering development of a pharmacologic agent for treatment of patients with diabetic kidney disease (DKD). The company was designing a Phase II trial in patients who had Type 2 Diabetes, Stage 3 chronic kidney disease (CKD) and macroalbuminuria.

Ensuring your product is accepted by regulatory authorities, compliant with classification, labeling and safety standards, and up-to-date with the latest regulatory changes is a complex process that requires extensive insight on current guidelines.

Physicochemical characteristics determine your chemical's testing requirements and regulatory pathways, so it's important to tailor your product chemistry analysis to address your specific needs and avoid delays.

Establishing the ecotoxicological profile of a chemical can be challenging due to the complex nature of the ecosystem.