A leading biotechnology client contracted with Labcorp for a human absorption, metabolism and excretion (AME) study using 14C to determine the excretory pathway and metabolite identification and potential enterohepatic recycling.

A mid-sized drug manufacturer was in Phase I clinical trials for a molecule designed to treat adenoviral infection. Their contract manufacturing organization (CMO) predicted a delay in drug production leading to a three- to six-month delay in study start-up.

Patient recruitment represents the biggest challenge in clinical trials.

Most people in our industry are familiar with the "Leaky Funnel" analogy that describes the model where we approach a large number of patients for inclusion in a study, but they leak out of the pipe at every juncture.

In 1848, the most famous Gold Rush in American history began at Sutter's Mill near present-day Coloma, California, shaping the U.S. economic map forever. In those days, there were no scientific tools to guide prospectors in their search. Sites of previous finds were the starting point for what became, for many, a shattered dream.

The industry is facing new and emerging human toxicity concerns driven by worldwide consumer demand and changes to global living standards. From added microplastics and other substances classed as persistent, bioaccumulative and toxic - there is increasing scrutiny placed on the safety profile of your chemical.

Gases, by their very nature, are difficult to handle and analyze. They are, however, generally bound by the same regulatory requirements as solid or liquid substances, so the same endpoint data is required. Physicochemical endpoints such as partition coefficient are requested because they are used to estimate the bioaccumulation potential of a substance.

QSARs are valuable in silico tools that are used in combination with other NATs to answer regulatory questions about the likely toxicity of a new chemical. Many different QSAR systems exist, each with different strengths and weaknesses.

WC11 2021 -- Atherosclerosis (gradual narrowing of the arteries) is an inflammatory process involving a series of progressive cellular events, including monocyte adhesion to the luminal endothelial surface.