The importance of the cynomolgus macaque’s origin in drug safety assessment

Cynomolgus macaques are the most commonly used non-human primate species for drug safety assessment. However, recent supply shortages  have brought increased attention to the genetic differences between cynomolgus macaques of varying geographic origins. It is important to examine the relevance of geographic origin for cynomolgus macaques used in regulatory toxicology studies.

Key learnings from ECHA's review of the EOGRTS (OECD Test Guideline 443)

The extended one-generation reproductive toxicity study (EOGRTS) per OECD Test Guideline 443 is a crucial test for evaluating potential reproductive and developmental effects of chemicals. Recently, the European Chemicals Agency (ECHA) conducted an extensive review of EOGRTS  studies to assess the effectiveness of this test guideline and provide recommendations for improvement. This blog post summarizes  key learnings from ECHA's review and the impacts on current and future EOGRTS study design.

Cinven to sell minority stake in SYNLAB to strategic investor Labcorp

International private equity firm, Cinven, has reached an agreement to sell an indirect minority stake in SYNLAB, a leader in medical diagnostic services and specialty testing in Europe, to strategic investor Labcorp. Labcorp is a global leader of innovative and comprehensive laboratory services

LABCORP PRICES $650,000,000 IN 4.350% SENIOR NOTES DUE 2030, $500,000,000 IN 4.550% SENIOR NOTES DUE 2032 AND $850,000,000 IN 4.800% SENIOR NOTES DUE 2034

BURLINGTON, N.C. , Sept. 16, 2024 /PRNewswire/ -- Labcorp Holdings Inc. (NYSE:LH) ( Labcorp ) announced today that its wholly owned subsidiary, Laboratory Corporation of America Holdings (LCAH), has priced its offering of $2,000,000,000 in senior notes (the Offering).

Labcorp Completes Acquisition of Select Assets of BioReference Health's Diagnostics Business from OPKO Health

Enhances Labcorp's laboratory services network and expands access to its clinical services  BURLINGTON, N.C. and MIAMI , Sept. 16, 2024 /PRNewswire/ -- Labcorp (NYSE: LH), a global leader of innovative and comprehensive laboratory services, and OPKO Health, Inc.

How eating healthy food can reduce the risk of developing prostate cancer

September not only marks the official end of summer but also the beginning of Prostate Cancer Awareness Month. While it experienced a decline in the early and mid-2000s, prostate cancer has had a resurgence in recent years.

Why cell line screening is crucial for successul complement-dependent cytotoxicity (CDC) assay development

Highlighgt new approach to CDC Assays for mAb characterization and QC release testing