Cytotoxicity testing is a critical step in medical device evaluation, but it comes with many challenges. Factors like device composition, sample preparation and contamination can impact results. With so much riding on safety data, it's essential to understand these challenges.

SOT 2024 -- Acetone and ethanol are widely used in industrial processes and are found in common household products. In inhalation studies, these organic molecules are used as solvents to vaporize low-volatility chemicals to reach the target aerosol concentrations.

SOT 2024 -- The U.S. EPA OPPTS 870.6300 Test Guideline (TG), the OECD 426 TG and potential additions to OECD 443 study designs call for test batteries for assessing learning and memory (L&M) function in rodents around the time of weaning and at adulthood.

SOT 2024 -- The rat is a commonly used animal model for preclinical continuous intravenous infusion. Many continuous intravenous infusion models have been developed. Due to the possible irritant properties of some test articles, the favoured catherisation site has become the femoral vein.

SOT 2024 -- Developmental neurotoxicity (DNT) studies are a regulatory requirement for the testing of chemicals that may cause adverse neurodevelopmental outcomes.

SOT 2024 -- The purpose of this study was to define an approach within risk management to determine acceptable safety limits of an ultrasound gel for invasive applications based on the results of a systemic toxicity study using a wide range of concentrations of the gel.

IAT Congress 2024 -- Providing our animals with the best welfare possible is one of our main goals as animal technicians.

IAT Congress 2024 -- Rat tickling is a positive handling technique promoted by the NC3Rs. Labcorp successfully trialed and adopted rat tickling in early 2021. Rat tickling was being used for most studies; however, it was not recommended for pregnant animals, which was advised by the NC3Rs.

IAT Congress 2024 -- The test article for this study was an antibiotic to treat urinary tract infections (UTIs), one of the top recurring infectious ailments of the elderly.

Dr. Maryland Franklin, VP and enterprise head of cell and gene therapy, led a special presentation in Singapore on strategies for cell and gene therapy (CGT) development.