查找地点
有关时间、上门服务和预约查找地点
有关时间、上门服务和预约This test covers all coding nucleotides of gene IFNGR1, plus at least two and typically 20 flanking intronic nucleotides upstream and downstream of each coding exon, covering the conserved donor and acceptor splice sites, as well as typically 20 flanking nucleotides in the 5′ and 3′ UTR.
In cases in which a known mutation can be documented, the physician may prefer to order test 252727.
Test orders must include an attestation that the provider has the patient's informed consent for genetic testing. See sample physician office consent form: Consent for Genetic Testing. In the case of family tests (ie, known mutations), please submit the result report of the first patient tested in the family (the index case), if not performed at a LabCorp facility. Other family members are subsequently tested for the specific mutation found in the first patient tested.
In cases in which a known mutation can be documented, the physician may prefer to order test 252727. Test orders must include an attestation that the provider has the patient's informed consent for genetic testing. See sample physician office consent form: Consent for Genetic Testing. In the case of family tests (ie, known mutations), please submit the result report of the first patient tested in the family (the index case), if not performed at a LabCorp facility. Other family members are subsequently tested for the specific mutation found in the first patient tested. In cases in which a known mutation can be documented, the physician may prefer to order test 252727. Test orders must include an attestation that the provider has the patient's informed consent for genetic testing. See sample physician office consent form: Consent for Genetic Testing. In the case of family tests (ie, known mutations), please submit the result report of the first patient tested in the family (the index case), if not performed at a LabCorp facility. Other family members are subsequently tested for the specific mutation found in the first patient tested. |
In cases in which a known mutation can be documented, the physician may prefer to order test 252727. Test orders must include an attestation that the provider has the patient's informed consent for genetic testing. See sample physician office consent form: Consent for Genetic Testing. In the case of family tests (ie, known mutations), please submit the result report of the first patient tested in the family (the index case), if not performed at a LabCorp facility. Other family members are subsequently tested for the specific mutation found in the first patient tested. In cases in which a known mutation can be documented, the physician may prefer to order test 252727. Test orders must include an attestation that the provider has the patient's informed consent for genetic testing. See sample physician office consent form: Consent for Genetic Testing. In the case of family tests (ie, known mutations), please submit the result report of the first patient tested in the family (the index case), if not performed at a LabCorp facility. Other family members are subsequently tested for the specific mutation found in the first patient tested. |
28 - 35 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
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28 - 35 days |
For more information, please view the literature below.
Consent for Genetic Testing (Consentimiento para análisis genético)
Whole blood; DNA is accepted (Call 800-345-4363 for DNA collection information.)
2 mL
Lavender-top (EDTA) tube
Samples may be stored for brief periods at 4°C. Ship overnight at room temperature.
Maintain specimen at room temperature.
Container broken or leaking; container not labeled or label not legible; improper anticoagulant
Confirm a clinical diagnosis of IFNGR1; guide therapy; detect carriers; allow early diagnosis in family members
This method does not reliably detect mosaic variants; large deletions; large duplications, inversions, or other rearrangements; or deep intronic variants. It may be affected by allele-dropout, it may not allow determination of the exact numbers of T/A or microsatellite repeats, and it does not allow any conclusion as to whether two heterozygous variants are present on the same or on different chromosome copies.
Results of this test are for investigational purposes only. The performance characteristics of this assay have been determined by LabCorp. The result should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.
DNA sequencing
Normal equals reference sequence or variants that are known or predicted to be benign; abnormal equals all other variants.
Mendelian susceptibility to mycobacterial disease (MSMD), or familial atypical mycobacteriosis, is an inherited immune disorder characterized by the inability to clear mycobacterial infections. Interferon-γ receptor deficiency (IFNGRD) is the most common cause of NSMD and has been associated with mutations in the gene IFNGR1 or IFNGR2. Depending on the exact mutation, disease severity can range from a mild form, which is easily treatable with prophylactic antibiotics and interferon-γ therapy, to a severe form, for which stem-cell transplantation is recommended. Mode of inheritance is typically recessive for the more severe forms and can be recessive or dominant for the milder forms. Genetic testing can confirm a clinical diagnosis of IFNGRD, clarify the mode of inheritance, and detect mutation carriers within affected families.
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