Synonyms
- Crohn's Disease
- IBD
- Ulcerative Colitis
Test Includes
Atypical perinuclear antineutrophil cytoplasmic antibodies (pANCA); Saccharomyces cerevisiae, IgA; Saccharomyces cerevisiae, IgG
Expected Turnaround Time
2 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
Specimen Requirements
Specimen
Serum
Volume
1.5 mL
Minimum Volume
0.7 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection
Specimen should be free of bacterial contamination, hemolysis, and lipemia.
Storage Instructions
Refrigerate
Causes for Rejection
Hemolysis; lipemia; bacterial contamination
Test Details
Use
Rule out Crohn's disease and ulcerative colitis
Methodology
Atypical ANCA: indirect fluorescent antibody (IFA); Saccharomyces cerevisiae, IgA, and IgG: enzyme immunoassay (EIA)
Reference Interval
• Saccharomyces cerevisiae, IgA: negative: <20.0
• Saccharomyces cerevisiae, IgG: equivocal: 20.1−24.9; positive: ≥25.0
• Atypical antineutrophil cytoplasmic antibodies: negative: <1:20
Additional Information
IgA and IgG antibody testing for S cerevisiae is useful adjunct testing for differentiating Crohn's disease and ulcerative colitis. Nearly 80% of Crohn's disease patients are positive for either IgA or IgG. In ulcerative colitis, <15% are positive for IgG, and <2% are positive for IgA. Fewer than 5% of healthy controls are positive for either IgG or IgA antibody, and no healthy controls had antibody for both. The atypical ANCA pattern has been observed in a significant percentage of patients with ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 164830 | Inflammatory Bowel Disease-IBD | 87551-8 | 164658 | Saccharomyces cerevisiae, IgG | Units | 6713-2 |
| 164830 | Inflammatory Bowel Disease-IBD | 87551-8 | 164659 | Saccharomyces cerevisiae, IgA | Units | 31032-6 |
| 164830 | Inflammatory Bowel Disease-IBD | 87551-8 | 162402 | Atypical pANCA | titer | 49503-6 |
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