Celiac Antibodies tTG IgA and Total IgA With Reflex to tTG IgG and DGP IgG
CPT:
82784; 86364
Synonyms
- IgA
- Tissue Transglutaminase (tTG)
Expected Turnaround Time
2 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
Test Details
Use
Aid in the diagnosis of gluten-sensitive enteropathies
Methodology
Enzyme immunoassay (EIA)
Additional Information
Celiac disease is a gluten enteropathy occurring in both children and adults. The disease is probably underdiagnosed in that it may affect as much as 1% of the population in the United States. The condition is characterized by a sensitivity to gluten (found in wheat, barley, and rye) that causes inflammation and atrophy of the villi of the small intestine, malabsorption, etc. This sensitivity to gluten may also be seen in dermatitis herpetiformis. Strict avoidance of gluten in the diet will control disease activity, and antibodies to serum markers will disappear with time.
References
Agardh D. Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease. Clin Gastroenterol Hepatol. 2007 Nov;5(11):1276-1281.17683995
Biagi F, Pezzimenti D, Campanella J, Vadacca GB, Corazza GR. Endomysial and tissue transglutaminase antibodies in coeliac sera: a comparison not influenced by previous serologic testing. Scand J Gastroenterol. 2001 Sep;36(9):955-958.11521986
Burgin-Wolff A, Gaze H, Hadziselimovic F, et al. Antigliadin and antiendomysium antibody determination for coeliac disease. Arch Dis Child. 1991 Aug;66(8):941-947.1819255
Calabuig M, Torregosa R, Polo P, et al. Serologic markers and celiac disease: a new diagnostic approach? Pediatr Gastroenterol Nutr. 1990 May;10(4):435-442.2193137
Green PH, Jabri B. Coeliac disease. Lancet. 2003 Aug 2;362(9381):383-391.12907013
Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005 Jan;40(1):1-19.15625418
Kaukinen K, Collin P, Laurila K, Kaartinen T, Partanen J, Maki M. Resurrection of gliadin antibodies in coeliac disease. Deamidated gliadin peptide antibody test provides additional diagnostic benefit. Scand J Gastroenterol. 2007 Dec;42(12):1428-1433.17852878
National Institutes of Health Consensus Development Conference Statement on Celiac Disease, 2004.
Pruessner HT. Detecting celiac disease in your patients. Am Fam Physician. 1998 Mar 1;57(5):1023-1034, 1039-1041.9518950
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 164047 | Celiac Ab tTG TIgA w/Rflx | 94493-4 | 164643 | t-Transglutaminase (tTG) IgA | U/mL | 31017-7 |
| 164047 | Celiac Ab tTG TIgA w/Rflx | 94493-4 | 001784 | Immunoglobulin A, Qn, Serum | mg/dL | 2458-8 |
| Reflex Table for Immunoglobulin A, Qn, Serum | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 164048 | Glia(IgG)+tTG(IgG) | 161693 | Deamidated Gliadin Abs, IgG | units | 58710-5 |
| Reflex Table for Immunoglobulin A, Qn, Serum | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 164048 | Glia(IgG)+tTG(IgG) | 164989 | t-Transglutaminase (tTG) IgG | U/mL | 32998-7 |
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