Chromosome Analysis, Tissue Biopsies (Products of Conception, Skin)
CPT:
Contact CPT coding department at 800-222-7566, ext 6-8400.
Synonyms
- Long-term Culture, Fibroblast Karyotype Study
- Placental Tissue Chromosome Analysis
- Spontaneous Abortion Chromosome Analysis
- Tissue Karyotype
Test Includes
20 Metaphases counted per study; 2 to 3 banded karyotypes per study
Special Instructions
Please include clinical information, previous cytogenetic report or karyotype.
If prior Cell-free DNA/NIPT studies have been performed, include copy of the report.
Call 800-345-4363 if there are any questions. FISH from paraffin blocks can be ordered on fixed specimen with Fluorescence in situ Hybridization (FISH), Paraffin Block [510825].
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Please include clinical information, previous cytogenetic report or karyotype. If prior Call 800-345-4363 if there any any questions. FISH from paraffin blocks can be ordered on fixed specimen with Fluorescence in situ Hybridization (FISH), Paraffin Block [510825]. |
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Please include clinical information, previous cytogenetic report or karyotype. If prior Cell-free DNA/NIPT studies have been performed, include copy of the report. Call 800-345-4363 if there are any questions. FISH from paraffin blocks can be ordered on fixed specimen with Fluorescence in situ Hybridization (FISH), Paraffin Block [510825]. |
Expected Turnaround Time
11 - 16 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Tissue, skin, products of conception, placental biopsy
Volume
2 to 4 mm³
Container
Submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' basal salt solution or Labcorp transport medium.
The transport tube (a sterile specimen container with transport medium) is available from Labcorp. Please call customer service at 800-345-4363. Do not use urine containers for shipping.
Saline is not recommended for transport. Do not use urine containers for shipping.
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Submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' basal salt solution or Labcorp transport medium. The transport tube (a sterile specimen container with transport medium) is available from Labcorp. Please call customer service at 800-345-4363. Do not use urine containers for shipping. Saline is not recommended for transport. Do not use urine containers for shipping. |
Collection
Aseptically obtain a small piece of tissue with subepidermal layers. Best results are obtained from placental villi, which remain viable much longer than fetal tissue. This is especially true in stillborn cases in which both cord blood and tissue samples are often not viable. If specimen is a product of conception, submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' basal salt solution or Labcorp transport medium.
Storage Instructions
Refrigerate. Do not freeze.
Causes for Rejection
Gross contamination; necrotic tissue; specimen in fixative
Test Details
Use
This test is used to evaluate possible chromosomal abnormalities as the cause of miscarriage, as well as an extended study of mosaicism found in blood chromosome analysis.
Limitations
Some products of conception may only contain maternal tissue.
Methodology
Tissue culture following enzymatic digestion of tissue. Standard harvesting and G-banding procedures are used with 20 metaphases examined and two karyotypes prepared.
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