查找地点
有关时间、上门服务和预约查找地点
有关时间、上门服务和预约This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample. This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample. |
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample. This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample. |
2 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
2 - 4 days 2 - 4 days |
2 - 4 days 2 - 4 days |
Serum
Serum Serum |
Serum Serum |
0.5 mL
0.5 mL 0.5 mL |
0.5 mL 0.5 mL |
0.2 mL (Note: This volume does not allow for repeat testing.)
Red-top tube or gel-barrier tube
Red-top tube or gel-barrier tube Red-top tube or gel-barrier tube |
Red-top tube or gel-barrier tube Red-top tube or gel-barrier tube |
Separate serum from cells. Transfer separated serum to a plastic transport tube. Please include the patient's age on the test request form.
Refrigerate.
Temperature | Period |
---|---|
Room temperature | 3 days |
Refrigerated | 7 days |
Frozen | 90 days |
Freeze/thaw cycles | Stable x3 |
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Plasma specimen
The IDS-iSYS Insulin-like Growth Factor-I (IGF-I) assay is an in vitro diagnostic device intended for the quantitative determination of IGF-I in human serum or plasma on the IDS system. Results are to be used in conjunction with other clinical and laboratory data to assist the clinician in the assessment of growth disorders.
The IDS-iSYS Insulin-like Growth Factor-I (IGF-I) assay is an in vitro diagnostic device intended for the quantitative determination of IGF-I in human serum or plasma on the IDS system. Results are to be used in conjunction with other clinical and laboratory data to assist the clinician in the assessment of growth disorders. The IDS-iSYS Insulin-like Growth Factor-I (IGF-I) assay is an in vitro diagnostic device intended for the quantitative determination of IGF-I in human serum or plasma on the IDS system. Results are to be used in conjunction with other clinical and laboratory data to assist the clinician in the assessment of growth disorders. |
The IDS-iSYS Insulin-like Growth Factor-I (IGF-I) assay is an in vitro diagnostic device intended for the quantitative determination of IGF-I in human serum or plasma on the IDS system. Results are to be used in conjunction with other clinical and laboratory data to assist the clinician in the assessment of growth disorders. The IDS-iSYS Insulin-like Growth Factor-I (IGF-I) assay is an in vitro diagnostic device intended for the quantitative determination of IGF-I in human serum or plasma on the IDS system. Results are to be used in conjunction with other clinical and laboratory data to assist the clinician in the assessment of growth disorders. |
Malnutrition will cause low somatomedin-C levels in spite of normal amounts of circulating growth hormone. The Sm-C level does not distinguish pituitary dwarfism from constitutional delay of growth and development.2
Malnutrition will cause low somatomedin-C levels in spite of normal amounts of circulating growth hormone. The Sm-C level does not distinguish pituitary dwarfism from constitutional delay of growth and development.2 Malnutrition will cause low somatomedin-C levels in spite of normal amounts of circulating growth hormone. The Sm-C level does not distinguish pituitary dwarfism from constitutional delay of growth and development.2 |
Malnutrition will cause low somatomedin-C levels in spite of normal amounts of circulating growth hormone. The Sm-C level does not distinguish pituitary dwarfism from constitutional delay of growth and development.2 Malnutrition will cause low somatomedin-C levels in spite of normal amounts of circulating growth hormone. The Sm-C level does not distinguish pituitary dwarfism from constitutional delay of growth and development.2 |
Immunochemiluminometric assay (ICMA)
Immunochemiluminometric assay (ICMA) Immunochemiluminometric assay (ICMA) |
Immunochemiluminometric assay (ICMA) Immunochemiluminometric assay (ICMA) |
See table.1
Age (y) | Male (ng/mL) | Female (ng/mL) | Age (y) | Male (ng/mL) | Female (ng/mL) |
---|---|---|---|---|---|
<1 | 18−79 | 14−106 | 18 | 145−506 | 117−430 |
1 | 20−108 | 23−136 | 19 | 122−435 | 113−408 |
2 | 24−135 | 30−163 | 20 | 116−410 | 108−384 |
3 | 28−148 | 34−192 | 21 to 25 | 109−353 | 101−347 |
4 | 32−165 | 38−217 | 26 to 30 | 101−307 | 91−308 |
5 | 37−196 | 46−243 | 31 to 35 | 95−290 | 84−281 |
6 | 43−229 | 56−268 | 36 to 40 | 90−278 | 79−259 |
7 | 50−243 | 64−288 | 41 to 45 | 84–270 | 74−239 |
8 | 59−275 | 74−337 | 46 to 50 | 81−263 | 70−225 |
9 | 67−315 | 81−405 | 51 to 55 | 74-−255 | 65−216 |
10 | 75−366 | 85−526 | 56 to 60 | 68−247 | 60−207 |
11 | 82−423 | 91−610 | 61 to 65 | 64−240 | 57−202 |
12 | 87−519 | 110−656 | 66 to 70 | 59−230 | 52−196 |
13 | 101–620 | 150–678 | 71 to 75 | 53−222 | 48−191 |
14 | 123−701 | 174−656 | 76 to 80 | 45−207 | 42−185 |
15 | 161−760 | 156−586 | 81 to 85 | 40−194 | 39−177 |
16 | 171−748 | 140−517 | 86 to 90 | 33−176 | 34−169 |
17 | 161−635 | 130−471 | >90 | Not established | Not established |
See table.1
See table.1
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See table.1
See table.1
|
IGF-1 is a relatively small peptide (molecular weight 7647) that is tightly bound in serum to one of several high affinity binding proteins.1 IGF-1 has approximately 50% sequence homology with proinsulin and has a number of biological activities similar to insulin. IGF-1 is a hormone that serves as the major effector of GH-stimulated somatic growth, as well as GH-independent anabolic responses in numerous tissues. IGF-1 has numerous growth-promoting effects, including mitogenic effects and the promotion of cartilage sulfation. Measurement of serum IGF-1 has been widely used in the diagnosis of disorders of GH secretion,2-6 management of disorders that lead to nutritional insufficiency, or catabolism,7-9 and monitoring both GH and IGF-1 replacement therapy. IGF-1 measurement may also have a role in the physiology of malignant disease.10,11
The IDS iSYS IGF-1 assay conforms to the recommendations outlined in the recently published consensus statement on the standardization and evaluation of IGF-1 assays.12 The assay is calibrated to the WHO recombinant reference standard 02/254 for IGF-1.13 Reference intervals for IGF-I using the IDS IGF-I were determined in a clinical routine study population from the United States.13,14 The cohort included 778,173 males and 710,752 females, aged from 0 to 90 years, who were representative of the overall United States population in terms of gender, race and ethnicity. Reference intervals were adjusted for age and sex using a modified Hoffman approach.15
Daughaday WH, Hall K, Salmon WD Jr, Van den Brande JL, Van Wyk JJ. On the nomenclature of the somatomedins and insulin-like growth factors. J Clin Endocrinol Metab. 1987 Nov;65(5):1075-1076.3667879 DeGroot LJ, Jameson JL, eds. Endocrinology. 4th ed. Philadelphia, Pa: WB Saunders Co; 2001:2257-2268. Pearson OH, Arafah B, Brodkey J. Management of acromegaly. Ann Intern Med. 1981 Aug;95(2):225-227.7258874 Pintor C, Loche S, Cella SG, Müller EE, Baumann G. A child with phenotypic Laron dwarfism and normal somatomedin levels. N Engl J Med. 1989 Feb 9;320(6):376-379.2913494 Rappaport R, Prevot C, Brauner R. Somatomedin-C and growth in children with precocious puberty: a study of the effect of the level of growth hormone secretion. J Clin Endocrinol Metab. 1987 Dec;65(6):1112-1117.3680478 Underwood LE, D'Ercole AJ. Anterior pituitary gland and hypothalamus: Disorders affecting anterior pituitary function. In: Rudolph AM, Hoffman JI, eds. Pediatrics. 18th ed. Norwalk, Conn: Appleton & Lange; 1987:1454-1465. Watts NB, Keffer JH. Anterior pituitary and hypothalamus. Practical Endocrinology. 4th ed. Philadelphia, Pa: Lea & Febiger; 1989:11-36. Daughaday WH, Hall K, Salmon WD Jr, Van den Brande JL, Van Wyk JJ. On the nomenclature of the somatomedins and insulin-like growth factors. J Clin Endocrinol Metab. 1987 Nov;65(5):1075-1076.3667879 DeGroot LJ, Jameson JL, eds. Endocrinology. 4th ed. Philadelphia, Pa: WB Saunders Co; 2001:2257-2268. Pearson OH, Arafah B, Brodkey J. Management of acromegaly. Ann Intern Med. 1981 Aug;95(2):225-227.7258874 Pintor C, Loche S, Cella SG, Müller EE, Baumann G. A child with phenotypic Laron dwarfism and normal somatomedin levels. N Engl J Med. 1989 Feb 9;320(6):376-379.2913494 Rappaport R, Prevot C, Brauner R. Somatomedin-C and growth in children with precocious puberty: a study of the effect of the level of growth hormone secretion. J Clin Endocrinol Metab. 1987 Dec;65(6):1112-1117.3680478 Underwood LE, D'Ercole AJ. Anterior pituitary gland and hypothalamus: Disorders affecting anterior pituitary function. In: Rudolph AM, Hoffman JI, eds. Pediatrics. 18th ed. Norwalk, Conn: Appleton & Lange; 1987:1454-1465. Watts NB, Keffer JH. Anterior pituitary and hypothalamus. Practical Endocrinology. 4th ed. Philadelphia, Pa: Lea & Febiger; 1989:11-36. |
Daughaday WH, Hall K, Salmon WD Jr, Van den Brande JL, Van Wyk JJ. On the nomenclature of the somatomedins and insulin-like growth factors. J Clin Endocrinol Metab. 1987 Nov;65(5):1075-1076.3667879 DeGroot LJ, Jameson JL, eds. Endocrinology. 4th ed. Philadelphia, Pa: WB Saunders Co; 2001:2257-2268. Pearson OH, Arafah B, Brodkey J. Management of acromegaly. Ann Intern Med. 1981 Aug;95(2):225-227.7258874 Pintor C, Loche S, Cella SG, Müller EE, Baumann G. A child with phenotypic Laron dwarfism and normal somatomedin levels. N Engl J Med. 1989 Feb 9;320(6):376-379.2913494 Rappaport R, Prevot C, Brauner R. Somatomedin-C and growth in children with precocious puberty: a study of the effect of the level of growth hormone secretion. J Clin Endocrinol Metab. 1987 Dec;65(6):1112-1117.3680478 Underwood LE, D'Ercole AJ. Anterior pituitary gland and hypothalamus: Disorders affecting anterior pituitary function. In: Rudolph AM, Hoffman JI, eds. Pediatrics. 18th ed. Norwalk, Conn: Appleton & Lange; 1987:1454-1465. Watts NB, Keffer JH. Anterior pituitary and hypothalamus. Practical Endocrinology. 4th ed. Philadelphia, Pa: Lea & Febiger; 1989:11-36. Daughaday WH, Hall K, Salmon WD Jr, Van den Brande JL, Van Wyk JJ. On the nomenclature of the somatomedins and insulin-like growth factors. J Clin Endocrinol Metab. 1987 Nov;65(5):1075-1076.3667879 DeGroot LJ, Jameson JL, eds. Endocrinology. 4th ed. Philadelphia, Pa: WB Saunders Co; 2001:2257-2268. Pearson OH, Arafah B, Brodkey J. Management of acromegaly. Ann Intern Med. 1981 Aug;95(2):225-227.7258874 Pintor C, Loche S, Cella SG, Müller EE, Baumann G. A child with phenotypic Laron dwarfism and normal somatomedin levels. N Engl J Med. 1989 Feb 9;320(6):376-379.2913494 Rappaport R, Prevot C, Brauner R. Somatomedin-C and growth in children with precocious puberty: a study of the effect of the level of growth hormone secretion. J Clin Endocrinol Metab. 1987 Dec;65(6):1112-1117.3680478 Underwood LE, D'Ercole AJ. Anterior pituitary gland and hypothalamus: Disorders affecting anterior pituitary function. In: Rudolph AM, Hoffman JI, eds. Pediatrics. 18th ed. Norwalk, Conn: Appleton & Lange; 1987:1454-1465. Watts NB, Keffer JH. Anterior pituitary and hypothalamus. Practical Endocrinology. 4th ed. Philadelphia, Pa: Lea & Febiger; 1989:11-36. |
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