Acquired Thrombophilia
The incidence of venous thrombosis increases dramatically with age. The rate of occurrences changes from approximately one per 100,000 individuals younger than 40 years of age to one per 1000 individuals older than 75.1 A number of acquired conditions that are associated with an increased risk of thrombosis have been identified. They are listed in the table. 2
|
Antiphospholipid antibodies (see below) |
Malignancy |
|
Atrial fibrillation |
Myeloproliferative disorders |
|
Congestive heart failure |
Nephrotic syndrome |
|
Diabetes mellitus |
Oral contraceptive therapy |
|
Estrogen therapy |
Paroxysmal nocturnal hemoglobinuria |
|
Heparin-induced thrombocytopenia |
Postoperative state |
|
Hypertension |
Pregnancy |
|
Hyperviscosity |
Thrombotic thrombocytopenic purpura |
|
Immobilization |
Trauma |
References
1. Adcock DM. Laboratory evaluation of venous thrombosis risk. Clin Hemost Rev.2003; 17(12):1,2,5,6,8.
2. Marlar RA, Adcock DM. The multifactorial threshold model of thrombotic risk. Clin Hemost Rev. 2003; 17(6):1,2,4-6.