Correlation of Nintedanib efficacy on fibrotic lesion deposition and lung function within a rat IPF model

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by increased deposition of extra cellular matrix and scarring of lung tissue over an extended period of time. The deposition of extra cellular matrix and scarring leads to a decline in lung function which is ultimately fatal. The aim of this study was to assess whether decreases in lung function capacity in a bleomycin-induced rat model of IPF correlated with the lung fibrotic lesion area and whether nintedanib treatment could attenuate these changes.