Human Immunodeficiency Virus 1 (HIV-1) Trofile® DNA (Monogram® Coreceptor Tropism), Whole Blood
CPT:
Call client services.
Expected Turnaround Time
29 - 33 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
For more information, please view the literature below.
Specimen Requirements
Specimen
Whole blood, frozen
Volume
4 mL
Container
Lavender-top (EDTA) tube
Collection
Collect specimen in lavender-top (EDTA) tube. Do not centrifuge. Ship frozen. To avoid delays in turnaround time, when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze.
Causes for Rejection
Insufficient volume; heparinized plasma; nonfrozen specimen
Test Details
Use
Detect HIV-1 coreceptor tropism; determine eligibility for CCR5 antagonist therapy such as Selzentry™ (maraviroc).
Limitations
This procedure should be used for patients with documented HIV-1 infection and undetectable viral loads.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Polymerase chain reaction (PCR) amplification and viral culture. Trofile™ is a registered trademark of Monogram Biosciences.
References
Whitcomb JM, Huang W, Fransen S, et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob Agents Chemother. 2007 Feb; 51(2):566-575. 17116663
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 829670 | Trofile(R) DNA | 550341 | Trofile(R) DNA PDF | 51969-4 | ||
| 829670 | Trofile(R) DNA | 550347 | Tropotype: | 80690-1 | ||
| 829670 | Trofile(R) DNA | 829671 | Trofile(R) DNA | 50790-5 | ||
| 829670 | Trofile(R) DNA | 829672 | Trofile(R) DNA Interpretation | 62364-5 |
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