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Connective Tissue Disease (CTD) Cascade

Test Number 520340
Test number copied
CPT 86038
Synonyms
  • Autoimmune (ANA) Rheumatic Disease

Test Details

Methodology

ELISA, RIA, IFA, Turbidity, ICMS

Result Turnaround Time

10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Connective Tissue Disease (CTD) Cascade Flyer

Lupus Comprehensive Testing Brochure

Use

This profile may be useful in diagnosing connective tissue or systemic autoimmune rheumatic disease.

Special Instructions

Antinuclear Antibodies (ANA) by IFA testing is performed.

1) If ANA is positive, the following tests are performed: Anti-DsDNA (double-stranded) Ab by Farr (Radioimmunoassay), Anti-Sm, Complement C3, Complement C4, Anti-U1 RNP, Anti-Ro (SS-A), Anti-La (SS-B), Anti-Chromatin, Anti-Centromere, Anti-Scl70, Anti-Jo1, Anti-Cardiolipin Abs, IgG and IgM, and Anti-Beta 2 Glycoprotein I Abs, IgG and IgM.

2) If ANA by IFA is negative, RheumAssure (Rheumatoid Factor by Turbidimetry, Anti-CCP (Cyclic Citrullinated Peptide) Abs, IgG and IgA, and 14-3-3-eta is performed.

3) If 14-3-3-eta is negative, the Anti-TPO (Thyroperoxidase) Ab and Anti-Thyroglobulin Ab are performed.

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

4 mL

Container

2 red-top or gel-barrier tubes; transfer tubes

Collection Instructions

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Stability Requirements

Temperature

Period

Refrigerated

14 days

Storage Instructions

Refrigerate.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520340 CTD Cascade 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Order Code520340
Order Code NameCTD Cascade
Order Loinc
Result Code520073
Result Code NameAnti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC42254-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520074 Homogeneous Pattern 20398-4
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520074
Result NameHomogeneous Pattern
UofM
Result LOINC20398-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520076 Nucleolar Pattern 20399-2
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520076
Result NameNucleolar Pattern
UofM
Result LOINC20399-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520233 Speckled Pattern 20401-6
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520233
Result NameSpeckled Pattern
UofM
Result LOINC20401-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520234 Centromere Pattern 53993-2
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520234
Result NameCentromere Pattern
UofM
Result LOINC53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520235 Spindle Apparatus Pattern 53003-0
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520235
Result NameSpindle Apparatus Pattern
UofM
Result LOINC53003-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520236 Nuclear Membrane Pattern 54006-2
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520236
Result NameNuclear Membrane Pattern
UofM
Result LOINC54006-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520237 Midbody Pattern 54155-7
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520237
Result NameMidbody Pattern
UofM
Result LOINC54155-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520238 Nuclear Dot Pattern 53998-1
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520238
Result NameNuclear Dot Pattern
UofM
Result LOINC53998-1
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520239 PCNA Pattern 53006-3
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520239
Result NamePCNA Pattern
UofM
Result LOINC53006-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520240 Centriole Pattern 53993-2
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520240
Result NameCentriole Pattern
UofM
Result LOINC53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520241 Note: 77202-0
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520241
Result NameNote:
UofM
Result LOINC77202-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520066 Anti-Centromere Ab by IFA(RDL) 5077-3
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520066
Result NameAnti-Centromere Ab by IFA(RDL)
UofM
Result LOINC5077-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520060 Anti-dsDNA Ab by Farr(RDL) IU/mL 47299-3
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520060
Result NameAnti-dsDNA Ab by Farr(RDL)
UofMIU/mL
Result LOINC47299-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520169 C3 Complement (RDL) mg/dL 4485-9
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520169
Result NameC3 Complement (RDL)
UofMmg/dL
Result LOINC4485-9
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520167 C4 Complement (RDL) mg/dL 4498-2
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520167
Result NameC4 Complement (RDL)
UofMmg/dL
Result LOINC4498-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520225 Anti-La (SS-B) Ab (RDL) Units 45142-7
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520225
Result NameAnti-La (SS-B) Ab (RDL)
UofMUnits
Result LOINC45142-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520216 Anti-Sm Ab (RDL) Units 11090-8
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520216
Result NameAnti-Sm Ab (RDL)
UofMUnits
Result LOINC11090-8
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520217 Anti-U1 RNP Ab (RDL) Units 57662-9
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520217
Result NameAnti-U1 RNP Ab (RDL)
UofMUnits
Result LOINC57662-9
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520224 Anti-Chromatin Ab, IgG (RDL) Units 32580-3
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520224
Result NameAnti-Chromatin Ab, IgG (RDL)
UofMUnits
Result LOINC32580-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520221 Anti-Scl-70 Ab (RDL) Units 26975-3
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520221
Result NameAnti-Scl-70 Ab (RDL)
UofMUnits
Result LOINC26975-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520259 Anti-Jo-1 Ab (RDL) Units 35333-4
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520259
Result NameAnti-Jo-1 Ab (RDL)
UofMUnits
Result LOINC35333-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520338 Interpretation 69048-7
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520338
Result NameInterpretation
UofM
Result LOINC69048-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520223 Anti-Cardiolipin Ab, IgG (RDL) GPL U/mL 3181-5
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520223
Result NameAnti-Cardiolipin Ab, IgG (RDL)
UofMGPL U/mL
Result LOINC3181-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520183 Anti-Cardiolipin Ab, IgM (RDL) MPL U/mL 3182-3
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520183
Result NameAnti-Cardiolipin Ab, IgM (RDL)
UofMMPL U/mL
Result LOINC3182-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520355 See below: N/A
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520355
Result NameSee below:
UofM
Result LOINCN/A
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520346 Anti-Beta2 Glycoprotein I IgG SGU 21108-6
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520346
Result NameAnti-Beta2 Glycoprotein I IgG
UofMSGU
Result LOINC21108-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520347 Anti-Beta2 Glycoprotein I IgM SMU 16136-4
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520347
Result NameAnti-Beta2 Glycoprotein I IgM
UofMSMU
Result LOINC16136-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520557 See below: N/A
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520557
Result NameSee below:
UofM
Result LOINCN/A
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520336 ANA POS Reflex 520357 See below: N/A
Reflex 1
Order Code520336
Order NameANA POS Reflex
Result Code520357
Result NameSee below:
UofM
Result LOINCN/A
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520337 ANA Neg Reflex 520132 Rheumatoid Factor by Turb RDL IU/mL 11572-5
Reflex 1
Order Code520337
Order NameANA Neg Reflex
Result Code520132
Result NameRheumatoid Factor by Turb RDL
UofMIU/mL
Result LOINC11572-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520337 ANA Neg Reflex 520047 Anti-CCP Ab, IgG + IgA (RDL) Units 57093-7
Reflex 1
Order Code520337
Order NameANA Neg Reflex
Result Code520047
Result NameAnti-CCP Ab, IgG + IgA (RDL)
UofMUnits
Result LOINC57093-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520337 ANA Neg Reflex 520206 14.3.3 ETA, Rheum. Arthritis ng/mL 75880-5
Reflex 1
Order Code520337
Order NameANA Neg Reflex
Result Code520206
Result Name14.3.3 ETA, Rheum. Arthritis
UofMng/mL
Result LOINC75880-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520337 ANA Neg Reflex 520206 14.3.3 ETA, Rheum. Arthritis ng/mL 75880-5
Reflex 1
Order Code520337
Order NameANA Neg Reflex
Result Code520206
Result Name14.3.3 ETA, Rheum. Arthritis
UofMng/mL
Result LOINC75880-5