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Anti-Dense Fine Speckled Protein 70 kDa (DFS70) Ab

CPT

83516

Synonyms
  • Anti-dense fine speckled
  • DFS70/LEDGFp75
  • LEDGFp75
  • Lens Epithelium-derived Growth Factor or transcription co-activator p75
  • SARD exclusion marker

Test Details

Methodology

Enzyme-linked immunosorbent assay (ELISA)

Result Turnaround Time

7 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Use

Anti-DFS70 antibodies may help identify individuals who do not have an ANA-associated Autoimmune Rheumatic Disease (AARD) especially in the absence of significant clinical findings.1 Anti-DFS70 Ab, especially when positive in isolation (i.e. in the absence of AARD-associated autoantibodies), may prevent unnecessary referrals and examinations of ANA-positive individuals.2

Limitations

This test should be used with clinical findings and other autoimmune testing; it cannot be used alone to rule out autoimmune disease.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Footnotes

1. Conrad K, Röber N, Andrade LEC, Mahler M. The Clinical Relevance of Anti-DFS70 Autoantibodies. Clin Rev Allergy Immunol. 2017 Apr;52(2):202-216.27350273
2. Fitch-Rogalsky C, Steber W, Mahler M, et al. Clinical and Serological Features of Patients Referred through a Rheumatology Triage System because of Positive Antinuclear Antibodies. PLoS One. 2014 Apr 4;9(4):e93812.24705829

Custom Additional Information

Anti-DFS70 antibodies target the dense fine speckled protein of 70 kDa which is identical to Lens Epithelium-Derived Growth Factor or transcription co-activator p75 (LEDGFp75). They are detectable in 2% to 22% of healthy individuals and in less than 1% of patients with AARD are of unknown clinical significance.

Specimen Requirements

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL

Container

Red-top tube; serum from red-top tube; serum from a gel tube; or serum gel tube

Collection Instructions

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Stability Requirements

TemperaturePeriod
Room temperature14 days
Refrigerated14 days
Frozen14 days
Freeze/thaw cyclesStable x3

Storage Instructions

Refrigerate or freeze.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520313 Anti-DFS70 Ab 95129-3 520314 Anti-DFS70 Ab Units 95129-3
Order Code520313
Order Code NameAnti-DFS70 Ab
Order Loinc95129-3
Result Code520314
Result Code NameAnti-DFS70 Ab
UofMUnits
Result LOINC95129-3