Test Details
Methodology
Immunofluorescence (IFA)
Result Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Diagnosis of inflammatory demyelinating diseases (IDD) with similar phenotype to neuromyelitis optica spectrum disorder (NMOSD), including optic neuritis (single or bilateral) and transverse myelitis; diagnosis of autoimmune myelin oligodendrocyte glycoprotein (MOG)-opathy; diagnosis of neuromyelitis optica (NMO); distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease; diagnosis of ADEM; prediction of a relapsing disease course
Special Instructions
If reflex test is performed, additional charges/CPT code(s) may apply.
Limitations
MOG IgG antibody titers may assist in monitoring disease course and prognosis, but their role is imperfect. Antibody titers may increase but may not be predictive of relapses or attacks. MOG IgG antibodies may become undetectable with immunosuppression, but this does not necessarily indicate clinical response.
Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
References
Specimen Requirements
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL (Note: This volume does not allow for repeat testing.)
Container
Serum from a red-top tube, gel-barrier tube, or serum transfer tube
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; grossly lipemic
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 505310 | Anti-MOG, Serum | 91545-4 | 505311 | MOG Antibody, Cell-based IFA | 91545-4 | |
| Order Code | 505310 | |||||
| Order Code Name | Anti-MOG, Serum | |||||
| Order Loinc | 91545-4 | |||||
| Result Code | 505311 | |||||
| Result Code Name | MOG Antibody, Cell-based IFA | |||||
| UofM | ||||||
| Result LOINC | 91545-4 |
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 505312 | Anti-MOG Antibody Titer, Serum | 505312 | Anti-MOG Antibody Titer, Serum | 91544-7 | |
| Reflex 1 | ||||||
| Order Code | 505312 | |||||
| Order Name | Anti-MOG Antibody Titer, Serum | |||||
| Result Code | 505312 | |||||
| Result Name | Anti-MOG Antibody Titer, Serum | |||||
| UofM | ||||||
| Result LOINC | 91544-7 | |||||