Test Includes
D-Dimer; Ferritin, Serum; Lactic Acid Dehydrogenase (LD); Neutrophil to Lymphocyte Ratio (NLR), Complete Blood Count (CBC) With Differential and Platelet
Expected Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum, plasma, and whole blood
Volume
3 mL serum, 2 mL plasma (sodium citrate), and 4 mL whole blood (EDTA)
Minimum Volume
2 mL serum, 1 mL plasma (sodium citrate), and 4 mL whole blood (Note: This volume does not allow for repeat testing.)
Container
Gel-barrier tube, blue-top (sodium citrate) tube, and lavender-top (EDTA) tube
Collection
Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples. When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge and carefully remove the plasma using a plastic transfer pipette, being careful not to disturb the cells.Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze plasma within four hours of blood collection and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit seperate frozen specimens for each test requested.
Storage Instructions
Frozen: Plasma
Room temperature: Serum and whole blood (EDTA)
Test Details
Use
Assessment of patients at risk of mortality from COVID-19 disease
Methodology
See individual test components.
References
Aloisio E, Chibireva M, Serafini L, et al. A Comprehensive Appraisal of Laboratory Biochemistry Tests as Major Predictors of COVID-19 Severity. Arch Pathol Lab Med. 2020 Dec 1;144(12):1457-1464.32649222
Cicculo A, Borghetti A, Dal Verme LZ, et al. Neutrophil-to-lymphocyte ratio and clinical outcome in COVID-19: a report from the Italian front line. Int J Antimicrob Agents. 2020 Aug;56(2):106017.32437920
Gao Y, Li T, Han M, et al. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol. 2020 Jul;92(7):791-796.32181911
Kerboua KE. NLR: A Cost-effective Nomogram to Guide Therapeutic Interventions in COVID-19. Immunol Invest. 2021 Jan;50(1):92-100.32482134
Tatum D, Taghavi S, Houghton A, Stover J, Toraih E, Duchesne J. Neutrophil-to-lymphocyte ratio and outcomes in Louisiana COVID-19 patients. Shock. 2020 Nov;54(5):652-658.32554992
Tjendra Y, Al Mana AF, Espejo AP, et al. Predicting Disease Severity and Outcome in COVID-19 Patients. Arch Pathol Lab Med. 2020 Dec 1;144(12):1465-1474.32818235
Velavan TP, Meyer CG. Mild versus severe COVID-19: Laboratory markers. Int J Infect Dis. 2020 Jun;95:304-307.32344011
Yang AP, Liu JP, Tao WQ, Li HM. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol. 2020 Jul;84:106504.32304994
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 164081 | COVID-19 Poor Outcomes Risk | 001115 | LDH | IU/L | 14804-9 | |
| 164081 | COVID-19 Poor Outcomes Risk | 004598 | Ferritin | ng/mL | 2276-4 | |
| 164081 | COVID-19 Poor Outcomes Risk | 115206 | D-Dimer | mg/L FEU | 48065-7 | |
| 164081 | COVID-19 Poor Outcomes Risk | 005025 | WBC | x10E3/uL | 6690-2 | |
| 164081 | COVID-19 Poor Outcomes Risk | 005033 | RBC | x10E6/uL | 789-8 | |
| 164081 | COVID-19 Poor Outcomes Risk | 005041 | Hemoglobin | g/dL | 718-7 | |
| 164081 | COVID-19 Poor Outcomes Risk | 005058 | Hematocrit | % | 4544-3 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015065 | MCV | fL | 787-2 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015073 | MCH | pg | 785-6 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015081 | MCHC | g/dL | 786-4 | |
| 164081 | COVID-19 Poor Outcomes Risk | 105007 | RDW | % | 788-0 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015172 | Platelets | x10E3/uL | 777-3 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015107 | Neutrophils | % | 770-8 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015123 | Lymphs | % | 736-9 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015131 | Monocytes | % | 5905-5 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015149 | Eos | % | 713-8 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015156 | Basos | % | 706-2 | |
| 164081 | COVID-19 Poor Outcomes Risk | 115398 | Immature Cells | N/A | ||
| 164081 | COVID-19 Poor Outcomes Risk | 015909 | Neutrophils (Absolute) | x10E3/uL | 751-8 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015917 | Lymphs (Absolute) | x10E3/uL | 731-0 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015912 | Neut/Lymph Ratio | ratio | N/A | |
| 164081 | COVID-19 Poor Outcomes Risk | 015925 | Monocytes(Absolute) | x10E3/uL | 742-7 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015933 | Eos (Absolute) | x10E3/uL | 711-2 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015941 | Baso (Absolute) | x10E3/uL | 704-7 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015108 | Immature Granulocytes | % | 71695-1 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015911 | Immature Grans (Abs) | x10E3/uL | 53115-2 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015945 | NRBC | % | 58413-6 | |
| 164081 | COVID-19 Poor Outcomes Risk | 015180 | Hematology Comments: | 18314-5 | ||
| 164081 | COVID-19 Poor Outcomes Risk | 164082 | Poor Outcomes Risk Panel | N/A |
| Reflex Table for Immature Cells | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 115399 | Immature Cells | 115400 | Bands | % | 35332-6 |
| Reflex Table for Immature Cells | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 115399 | Immature Cells | 115401 | Metamyelocytes | % | 28541-1 |
| Reflex Table for Immature Cells | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 115399 | Immature Cells | 115403 | Myelocytes | % | 26498-6 |
| Reflex Table for Immature Cells | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 115399 | Immature Cells | 115404 | Promyelocytes | % | 26498-6 |
| Reflex Table for Immature Cells | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 115399 | Immature Cells | 115405 | Blasts/blast like cells | % | 26498-6 |
| Reflex Table for Immature Cells | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 115399 | Immature Cells | 115406 | Megakaryocytes | % | 19252-6 |
| Reflex Table for Immature Cells | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 115399 | Immature Cells | 115265 | Other, Lineage Uncertain | % | 55433-7 |
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf