COVID-19 Induced Thrombotic Microangiopathy Profile
CPT:
83615; 85240; 85246; 85379; 85397; 86162
Test Includes
ADAMTS13 Activity; Complement, Total (CH50); D-Dimer; Factor VIII Activity; Lactic Acid Dehydrogenase (LD); von Willebrand Profile
Expected Turnaround Time
2 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum and plasma
Volume
2 mL serum and 4.5 mL plasma (sodium citrate)
Minimum Volume
1 mL serum and 3 mL plasma (sodium citrate) (Note: This volume does not allow for repeat testing.)
Container
Gel-barrier tube and blue-top (sodium citrate) tube
Collection
Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples. When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge and carefully remove the plasma using a plastic transfer pipette, being careful not to disturb the cells. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze plasma within four hours of blood collection and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit seperate frozen specimens for each test requested.
Storage Instructions
Frozen: Serum and plasma
Room temperature: Serum
Test Details
Use
Assessment of patients at high risk of COVID-19-associated thrombotic microangiopathy.
Limitations
For von Willebrand Factor (vWF) Antigen [086280]: This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approvedby the Food and Drug Administration.
Methodology
See individual test components.
References
Doevelaar A, Bachmann M, Hölzer B, et al. COVID-19 is associated with relative ADAMTS13 deficiency and VWF multimer formation resembling TTP. medRxiv preprint posted August 25, 2020. doi.org/10.1101/2020.08.23.20177824.
Goshua G, Pine AB, Meizlish ML, et al. Endoteliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. Lancet Haematol. 2020 Aug;7(8):e575-e582.32619411
Jodele S, Fukuda T, Vinks A, et al. Eculizumab Therapy in Children with Severe Hematopoietic Stem Cell Transplantation-Associated Thrombotic Microangiopathy. Biol Blood Marrow Transplant. 2014 Apr;20(4):518-525.24370861
Mancini I, Baronciani L, Artoni A, et al. The ADAMTS13-von Willebrand factor axis in COVID-19 patients. J Thromb Haemost. 2021 Feb;19(2):513-521.33230904
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 164044 | COVID-19 Microangiopathy Panel | 001941 | Complement, Total (CH50) | U/mL | 4532-8 | |
| 164044 | COVID-19 Microangiopathy Panel | 001115 | LDH | IU/L | 14804-9 | |
| 164044 | COVID-19 Microangiopathy Panel | 086264 | Factor VIII Activity | % | 3209-4 | |
| 164044 | COVID-19 Microangiopathy Panel | 086280 | von Willebrand Factor (vWF) Ag | % | 27816-8 | |
| 164044 | COVID-19 Microangiopathy Panel | 115206 | D-Dimer | mg/L FEU | 48065-7 | |
| 164044 | COVID-19 Microangiopathy Panel | 117928 | ADAMTS13 Activity | % | 53622-7 | |
| 164044 | COVID-19 Microangiopathy Panel | 164045 | Induced Thrombotic Panel | N/A |
| Reflex Table for ADAMTS13 Activity | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 117917 | Comment: | 117917 | Comment: | N/A | |
| Reflex Table for ADAMTS13 Activity | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 117931 | Comment | 117931 | Comment | N/A | |
© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.
CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf