Disseminated Intravascular Coagulation (DIC) Profile
CPT:
85049; 85362; 85379; 85384; 85610; 85730
Synonyms
- DIC Profile
Test Includes
D-dimer; fibrinogen; fibrinogen degradation products (FDP), plasma; platelet count; partial thromboplastin time (PTT); prothrombin time (PT)
Special Instructions
If the patient's hematocrit exceeds 55%, the volume of citrate in the collection tube must be adjusted. Refer to Coagulation Collection Procedures for directions.
Expected Turnaround Time
2 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
For more information, please view the literature below.
Procedures for Hemostasis and Thrombosis: A Clinical Test Compendium
Specimen Requirements
Specimen
Whole blood and plasma, frozen
Volume
5 mL EDTA whole blood, one citrated whole blood tube, and two transfer tubes with 1 mL frozen sodium citrate plasma in each tube
Container
Lavender-top (EDTA) tube and blue-top (sodium citrate) tubes
Collection
Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge and carefully remove the plasma using a plastic transfer pipette, being careful not to disturb the cells. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested.
Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.
Storage Instructions
Maintain whole blood at room temperature. Freeze plasma.
Patient Preparation
None
Causes for Rejection
Severe hemolysis; improper labeling; clotted specimen; specimen diluted with IV fluids; samples thawed in transit; improper sample type; sample out of stability
Test Details
Use
Identify the presence and follow the course of disseminated intravascular coagulation (DIC)
Methodology
See individual tests.
Footnotes
1. Adcock DM, Kressin DC, Marlar RA. Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing. Am J Clin Pathol. 1997 Jan; 107(1):105-110. 8980376
2. Reneke J, Etzell J, Leslie S, Ng VL, Gottfried EL. Prolonged prothrombin time and activated partial thromboplastin time due to underfilled specimen tubes with 109 mmol/L (3.2%) citrate anticoagulant. Am J Clin Pathol. 1998 Jun; 109(6):754-757. 9620035
3. National Committee for Clinical Laboratory Standardization. Collection, Transport, and Processing of Blood Specimens for Coagulation Testing and General Performance of Coagulation Assays; Approved Guideline. 5th ed. Villanova, Pa: NCCLS; 2008. Document H21-A5:28(5).
4. Gottfried EL, Adachi MM. Prothrombin time and activated partial thromboplastin time can be performed on the first tube. Am J Clin Pathol. 1997 Jun; 107(6):681-683. 9169665
5. McGlasson DL, More L, Best HA, Norris WL, Doe RH, Ray H. Drawing specimens for coagulation testing: Is a second tube necessary? Clin Lab Sci. 1999 May-Jun; 12(3):137-139. 10539100
References
Carey MJ, Rodgers GM. Disseminated intravascular coagulation: Clinical and laboratory aspects. Am J Hematol. 1998 Sep; 59(1):65-73. 9723580
Mammen EF. Disseminated intravascular coagulation (DIC). Clin Lab Sci. 2000 Fall; 13(4):239-245. 11586511
Yu M, Nardella A, Pechet L. Screening tests of disseminated intravascular coagulation: Guidelines for rapid and specific laboratory diagnosis. Crit Care Med. 2000 Jun; 28(6):1777-1780. 10890618
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 116012 | DIC Profile | 001610 | Fibrinogen Activity | mg/dL | 3255-7 | |
| 116012 | DIC Profile | 115402 | FDP, Plasma | ug/mL | 30226-5 | |
| 116012 | DIC Profile | 115107 | INR | 6301-6 | ||
| 116012 | DIC Profile | 015289 | Prothrombin Time | sec | 5902-2 | |
| 116012 | DIC Profile | 015116 | aPTT | sec | 14979-9 | |
| 116012 | DIC Profile | 015172 | Platelets | x10E3/uL | 777-3 | |
| 116012 | DIC Profile | 115206 | D-Dimer | mg/L FEU | 48065-7 |
| Reflex Table for INR | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 115109 | INR (Thromborel-S) | 115109 | INR (Thromborel-S) | 6301-6 | |
| Reflex Table for Prothrombin Time | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 015290 | PT (Thromborel-S) | 015290 | PT (Thromborel-S) | sec | 5902-2 |
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