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有关时间、上门服务和预约Idiopathic inflammatory myopathies (IIM), commonly known as myositis, are rare conditions that can affect multiple organs apart from muscle and often lead to a severe impairment of the quality of life.
Labcorp offers a myositis profile performed using RIPA and EIA methodologies. MyoMarker® 3 Plus profile includes both myositis-specific antibodies (MSA) and myositis-associated antibodies (MAA), as well as anti-SAE-1 antibody.
IIMs are a heterogeneous group of disorders characterized by muscle weakness, resulting from chronic muscle inflammation of unknown cause. Patients with IIM have a variety of autoantibodies with various clinical associations that fall into two main groups:
MSA are highly specific for patients with polymyositis (PM), dermatomyositis (DM), anti-synthetase syndrome, and necrotizing myositis
MAA appears in myositis overlap syndromes and in other connective tissue diseases, which correlate with certain clinical and/or pathophysiological conditions
*Individual components can be ordered separately
MSA are found only in patients with myositis and have been shown to be highly specific for patients with polymyositis (PM), dermatomyositis (DM), anti-synthetase syndrome, necrotizing myositis and overlap syndromes. MAA can be found in patients with overlap syndromes such as polymyositis/scleroderma and may also be found in non-overlap syndromes.
RIPA gel radiography utilizes immunoprecipitation, gel electrophoresis and autoradiography to identify radioisotope-labeled proteins from human erythroleukemic cell extracts that are targeted by autoantibodies in patient serum. RIPA gel radiography is a powerful, reliable technology that has been used and refined for more than 30 years to identify many PM/DM autoantibodies with high sensitivity, specificity and reproducibility. It is the original methodology of studies that defined various myositis-specific and myositis-associated antibodies.2
Other Myositis-Specific Antibodies |
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Anti-HMGCR Ab (RDL) Anti-cN-1A Ab (NT5c1A) IBM (RDL) |
Number | Name |
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520085 | MyoMarker® 3 Plus Profile (RDL) |
Myositis-Specific Antibodies | Myositis-Associated Antibodies |
---|---|
Anti-Jo-1 Anti-PL-7 Anti-PL-12 Anti-EJ Anti-OJ Anti-SRP Anti-Mi-2 Anti-TIF-1gamma (part of P155/140 Kd) Anti-MDA-5-Ab (CADM-140) Anti-NXP-2 (P140) Anti-SAE-1 |
Anti-PM/Scl-100 Anti-SS-A 52kD Anti-Ku Anti-U1 RNP Anti-U2 RNP Anti-U3 RNP (Fibrillarin) |
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