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Article

Bioanalytical methods, strategies and outlook for antibody-drug conjugate trials

April 8, 2024

Antibody-drug conjugates (ADCs) are formed by antibodies targeting a specific antigen or antibody fragment covalently attached to payloads (such as small molecule cytotoxic drugs) via a linker. The primary goal of ADCs is to target the payload to specific sites through the antibody, combining the potent cytotoxic effects of traditional small molecule drugs with the tumor-targeting characteristics of antibody drugs.